INDONAL MAN:

• It boosts male sex hormone metabolism, has beneficial and revitalising effects on the urinary and reproductive systems and is effective at relieving prostate problems
• Saw Palmetto maintains healthy testosterone metabolism in males and has a favourable effect on the proper function of the prostate and genitourinary tract

The packaging contains 120 capsules.

INDONAL MAN contains Indole-3-carbinol, a substance found in cruciferous vegetables, such as broccoli, kale, cabbage, cauliflower. The extract of the fruit of the saw palmetto maintains healthy testosterone metabolism and has a favourable effect on prostate and genitourinary tract function.

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a benign disease associated with a number of symptoms affecting approximately 50% of men aged 50 years or older and up to 75% of men aged 80 years and older. The most frequent symptoms include urinary urgency and intermittency, weak urine stream, sensation of incomplete bladder emptying, frequent and urgent urination during the day, and nocturia. BPH is caused by an overgrowth of prostate cells leading to urethral compression and urinal difficulties, which may result in serious complications, such as reduced renal function and urinary tract infections.

Saw palmetto extracts are among the most widely used plant extracts in the symptomatic treatment of urinary disorders (dysuria, pollakiuria, nocturia, urinary retention) caused by BPH. Research shows a number of mechanisms of action, including anti-androgenic and anti-oestrogenic actions, and growth factor inhibition. The most probable one is the antiandrogenic effect that inhibits the 5-α-reductase enzyme, which catalyses the conversion of testosterone into dihydrotestosterone (DHT). DHT is an intracellular androgen responsible for prostate growth regulation. Inhibitors of this enzyme induce apoptosis (death) in prostate epithelial cells, leading to a reduction in prostate volume.*2

Indole-3-carbinol is used for the prevention of tissue proliferation and prostate cancer. Among the effects reported, anti-oestrogen activity has been prevalent, it directly binds to oestrogen receptors and acts as an antagonist. In regard to prostate cancer, in vitro studies showed indole-3-carbinol inducing cancer cell death and its active metabolite diindolylmethane significantly suppressing the proliferation of prostate cancer cells (PC-3).*1 The results of another study showed that I3C inhibited prostate and colon cell growth. Scientific laboratory data showed that I3C and DIM inhibited PC3 prostate cancer cell growth. *3 DIM is an I3C metabolite generated by its breakdown in the acidic environment of the stomach.

Indonal Man Composition, 1 capsule:

150 mg of indole-3-carbinol, 100 mg of saw palmetto (Serenoa repens extract).

Dosage:

• Preventive treatment: 1 capsule a day for 3 months.
• In case of a medical finding: 2 capsules a day for 3 months.
• Weight over 70 kg: 3 capsules a day for 3 months.
• Take with food and adequate amounts of water!

Contraindications

• Not suitable for children below 15 years of age, pregnant and nursing women.
• The use is contraindicated in hypersensitivity to any of the product components and in patients taking medication for gastric acid secretion decrease.

Warning:

It is necessary to consult a doctor in cases of reproductive organ diseases. It is not recommended to use the product in combination with antacids, H2 blockers, and proton pump inhibitors; it can be used in combination with medicines, antibiotics and can also be used during radiotherapy as well as in conjunction with contraception. The recommended daily intake must not be exceeded. Nutritional supplements must not be used as a substitute for a balanced diet and a healthy lifestyle. Nutritional supplements must be kept out of the reach of small children. In case of the occurrence of undesirable effects, stop taking the product and consult a doctor. The product odour is characteristic of cruciferous vegetables and does not mean the quality of the product has deteriorated. Store at 10–25 °C in a dark place, no refrigerator required.
It is possible the smell is not very pleasant but it is characteristic of cruciferous vegetables that are laboratory processed.

*1 Zhang W.W. et al. 2014. Multiple therapeutic and preventive effects of 3,39-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia IN The Journal of Biomedical Research, Vol. 28, N.5, ISSN: pp. 339–348

*2 Silvia Fialová. 2013. Phytotherapy for benign prostatic hyperplasia IN Via pract., 2013. [online] Vol. 10. No 2. 2013 [cit. 2019-1-25]: pp. 65–68. URL:  http://www.viapractica.sk/index.php?page=pdf_view&pdf_id=6385&magazine_id=1

*3 Fazlul H. Sarkar Yiwei Li. 2004. Indole-3-Carbinol and Prostate Cancer In The Journal of Nutrition, [online] Volume 134, Issue 12, P. 3493S–3498S. [cit. 2019-1-25],URL:https://doi.org/10.1093/jn/134.12.3493S

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