Dangerous Estrogen Dominance and I3C

Articles and studies

03. May 2022

Dangerous Estrogen Dominance and I3C. Currently, this is a crucial issue that affects not only women but also men. Did you know that an excess of estrogen can cause a hormonal imbalance leading to infertility?

Dr. John Lee was the first to use the term: “estrogen dominance”, and spent several years searching for the cause of women’s problems such as PMS, endometriosis, ovarian cysts, fibroids, breast cancer, infertility, osteoporosis and menopause. Based on his clinical experience of women’s health and also from published research, he came to the conclusion that the health problems of many women (but also men) are caused by the excess of estrogen present. Estrogen has three basic types: estradiol, estrone, and estriol. Estradiol controls female sexual development, promotes the growth and function of female genitalia and secondary female sex characteristics, and participates in bone mineral homeostasis.

Independent studies from the USA prove that Indole-3-carbinol (I3C), present in cruciferous plants, affects hormonal activity:

  • Flushes out harmful estradiol (when estradiol ages, it metabolizes into the so-called 16 alpha hydroxyl), increasing the risk of cancer.
  • Supports the formation of new healthy estradiol (so-called 2 hydroxyl) by promoting the production of liver enzyme cytochrome P450. This enzyme subsequently supports the formation of healthy estradiol.
  • Reduces the risk of cancer by working to decrease estrogen activity. It does this by blocking hormone receptors on hormone-dependent cells in the breast and uterus.

Link to studies on the effect of I3C on hormones:




An overview of symptoms that can be caused or worsened by estrogen dominance:

acceleration of the aging process, allergies, breast tenderness, breast cysts, foggy thinking, exhaustion, hair loss, facial hair growth, higher risk of stroke, infertility, irritability, memory impairment, miscarriage, osteoporosis, PMS manifesting as reduced function, uterine cancer, fibroids, edema, cellulitis, gallbladder disease, and autoimmune diseases such as lupus and thyroiditis.

Article source:https://www.fertility.sk/sk_SK/plodnost-a-zdravie/ako-to-funguje/estrogeny.html

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