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Dietary indole-3-carbinol (I3C) has clinical benefits for both cervical cancer and laryngeal papillomatosis, and causes apoptosis of breast cancer cells in vitro.

The climacteric period can be depressing and complicated for many women. At the first symptoms and missed periods at this age, it is necessary to seek the help of a gynecologist who will assess the condition, carry out careful examinations and set up the correct treatment. The treatment is based on the supplementation of hormones, but the composition of the diet and the substance I3C are also excellent helpers during menopause. It has a beneficial effect on the hormonal balance of women and is especially beneficial during the menopause.

Indole-3-carbinol is a phytochemical obtained from cruciferous plants. After its consumption, several oligomeric components with different biological effectiveness are formed, including 3,3'-diindolylmethane. They are characterized by anti-estrogenic and anti-proliferative activity. Studies have yielded positive results when investigating the effect of indole-3-carbinol in various oncological diseases, demonstrating beneficial changes in estrogen metabolism. The use of indole-3-carbinol is applied in the prevention and treatment of papillomatous diseases caused by human papillomavirus, as well as in endometrial cancer and early stages of breast cancer. By influencing estrogen metabolism, glucose metabolism, and reducing insulin resistance, it appears to be a promising adjunctive treatment in polycystic ovary syndrome. Indole-3-carbinol is considered safe even with long-term use.

Recent research, including studies in labs and on people, shows that a substance called indole-3-carbinol may help prevent various cancers, including breast cancer. When taken by mouth, indole-3-carbinol can positively impact how our bodies handle estrogen. It changes the balance between two types of estrogen metabolites, where one type is linked to a higher risk of breast cancer, and the other is associated with a lower risk. This suggests that indole-3-carbinol could be a good option for clinical trials in women with an increased risk of breast cancer. Additionally, it seems to selectively target and stop the growth of breast cancer cells without affecting normal breast cells.

The indole derivative, indole-3-carbinol (I3C), is a naturally occurring substance in cabbage plants. This substance inhibits cell proliferation, arrests the cell cycle in the G1 phase, and induces apoptosis, thereby suppressing tumorigenesis. Its use could thus help in the prevention and treatment of some diseases, including cervical lesions. However, the molecular mechanisms by which indoles suppress tumorigenesis are not precisely known. Women with cervical intraepithelial neoplasia II and III (CIN II/III) have a lower 2:16α-hydroxyestrone ratio compared to women with physiologic findings on the cervix. I3C effectively increases the 2-hydroxylation of estrogen in liver cells and promotes the formation of 2-hydroxyestrone at the expense of 16α-hydroxyestrone. I3C could, therefore, be used as an adjunct in the treatment of cervical lesions. However, its application is broader. Currently, several preparations and nutritional supplements containing indole-3-carbinol are available on the market. The recommended daily dose of I3C is 200-400 mg twice daily for...

Dr. John Lee was the first to use the term: "estrogen dominance", and spent several years searching for the cause of women's problems such as PMS, endometriosis, ovarian cysts, fibroids, breast cancer, infertility, osteoporosis and menopause. Based on his clinical experience of women's health and also from published research, he came to the conclusion that the health problems of many women (but also men) are caused by the excess of estrogen present. Estrogen has three basic types: estradiol, estrone, and estriol. Estradiol controls female sexual development, promotes the growth and function of female genitalia and secondary female sex characteristics, and participates in bone mineral homeostasis.

Indonal Man positively affects the metabolism of male sex hormones, benefiting the urinary and sexual systems, and provides revitalizing effects in addressing prostate problems. The inclusion of Saw Palmetto, a key component, supports the metabolism of healthy testosterone in the male body and promotes the well-being of the prostate and urogenital tract.